SNPnexus is a comprehensive web-based variant annotation tool designed to simplify the selection and prioritisation of both known and novel genomic alterations. The platform provides deep insights into genomic consequences, predicted deleteriousness, population prevalence, disease associations, and more. Once the annotation is complete, our intuitive results interface allows you to filter and prioritise variants based on a diverse range functional and clinical criteria.
For more information on how to get started, please refer to our User Guide and Example sections.
Commercial users: Service providers or organisations requiring larger queries, or interested in a customised version of SNPnexus, are encourage to contact us at info@snp-nexus.org
SNPnexus Version 5: New features at a glance:
- Multi-File Upload: Submit up to 6 files (VCF or Text) simultaneously for comparative analysis.
- Pre-Filtering: Focus your analysis by chromosomal position or specific gene lists before processing.
- Maximum Variant Limit: The platform supports now up to 150000 variants. This applies to the total count across all uploaded files after the optional pre-filters have been applied.
label_important Follow the flow chart below to ensure your analysis runs smoothly:
Click here to fill the text area with an example.
You can upload up to 6 VCF or text files (tab-separated list in the format shown below).
Alternatively, You can upload 1 zip or tar.gz file with up to 6 files inside (Text or VCF).
| SNPnexus File Format | |||||
|---|---|---|---|---|---|
| Type | Chromosome or dbSNP | Position | Ref. Allele | Alt. Allele(s) | |
| chromosome | 2 | 189001450 | G | A | |
| chromosome | chr17 | 46010375 | T | C/A | |
| dbsnp | rs181890605 | ||||
After adding the files, click on Upload files and then Validate files. This will allow you to continue the process.