Below is a description of the key columns provided in your results:

Genomic Mapping:

• Variant ID: Identification of the variant in this sample. Usually The chromosome:position:ref_allele:alt_allele(s):strand
• Chrom: Chromosome
• Position: Variant start position on chromosome
• Alleles: Ref Allele/Alt Allele(s)
• dbSNP: dbSNP ID, if variant maps to a known dbSNP
• Contig Position: Variant contig and contig location
• Cytoband: Variant Cytogenetic location
• Overlapping Genes: Name of the gene(s) to which the variant is overlapped
• Upstream Gene: If variant is not overlapping any gene, the closest variant in the upstream.
• Downstream Gene: If variant is not overlapping any gene, the closest variant in the downstream.

Genomic Consequence:

• ID: Identification of the variant in this sample. Usually The chromosome:position:ref_allele:alt_allele(s)
• Chrom: Chromosome
• Position: Variant start position on chromosome
• Alleles: Ref Allele/Alt Allele(s)
• Consequence: Predicted function of the variant on the transcript.
• Transcript: Transcript name in the corresponding system (Ensembl, NCBI, CCDS)
• Canonical: True if the transcript is canonical
• Gene: Gene name in the corresponding system (Ensembl, NCBI, CCDS) and its HGVS symbol (if available)
• Protein: Protein name in the corresponding system (Ensembl, NCBI, CCDS)
• HGVS: HGVS nomenclature of the variant on the transcript or chromosome level
• HGVS Protein: HGVS nomenclature of the variant on the protein
• CDNA Position: Variant position on the CDNA
• CDS Position: Variant position on the CDS
• AA Position: Position of the first aminoacid affected in the resultant peptide chain
• Peptide Mutation: Wild peptide > Mutated Peptide
• Splice Distance: Distance to splice junction, if variant is intronic.

Non-Synonymous Single Nucleotide Mutations:

• ID: Identification of the variant in this sample. Usually The chromosome:position:ref_allele:alt_allele(s)
• Chrom: Chromosome
• Position: Variant start position on chromosome
• Ref Allele: Reference Allele
• Alt Allele: Observed Allele
• Wild AA: Reference amino acid
• Mutated AA: Mutated amino acid
• Transcript: Transcript affected by variant
• Gene: Gene affected by variant
• SIFT: SIFT Score and predicted deleteriousness
• PolyPhen: PolyPhen Score and predicted deleteriousness
• REVEL: REVEL Score and predicted deleteriousness
• AlphaMissense: AlphaMissense Score and predicted deleteriousness
• CADD: CADD Phred Score and predicted deleteriousness

Non-Coding Single Nucleotide Mutations:

• ID: Identification of the variant in this sample. Usually The chromosome:position:ref_allele:alt_allele(s)
• Chrom: Chromosome
• Position: Variant start position on chromosome
• Ref Allele: Reference Allele
• Alt Allele: Observed Allele
• ReMM: ReMM Score and predicted pathogenicity
• Jarvis: Jarvis Score and predicted pathogenicity
• CADD: CADD Phred Score and predicted pathogenicity

Population Frequency - ALFA:

• Total Frequency: Allele Frequency in the global population
• AFA Frequency: Allele Frequency in Individuals with African Ancestry
• AFO Frequency: Allele Frequency in African American population
• AFR Frequency: Allele Frequency in all African individuals (AFA and AFO individuals)
• ASN Frequency: Allele Frequency in all Asian population (EAS and OAS individuals, excluding South Asians)
• EAS Frequency: Allele Frequency in the East Asian population
• EUR Frequency: Allele Frequency in the European population
• LAC Frequency: Allele Frequency in Latin American individuals with Afro-Caribbean Ancestry
• LEN Frequency: Allele Frequency in Latin American individuals with mostly European and Native American Ancestry
• OAS Frequency: Allele Frequency in all Asian individuals excluding South or East Asian
• OTH Frequency: Allele Frequency in individuals with self-reported population is inconsistent
• SAS Frequency: Allele Frequency in the South Asian population

Population Frequency - 1000 Genomes:

• AFR Frequency: Allele Frequency in the African population
• AMR Frequency: Allele Frequency in the Latin American population
• EAS Frequency: Allele Frequency in the East Asian population
• EUR Frequency: Allele Frequency in the European population
• SAS Frequency: Allele Frequency in the South Asian population

Population Frequency - gnomAD:

• Total Frequency: Allele Frequency in the global population
• XX Frequency: Allele Frequency in Female individuals
• XY Frequency: Allele Frequency in Male individuals
• AFR Frequency: Allele Frequency in the African/African American population
• AMI Frequency: Allele Frequency in the Amish population
• AMR Frequency: Allele Frequency in the Admixed American population
• ASJ Frequency: Allele Frequency in the Ashkenazi Jewish population
• EAS Frequency: Allele Frequency in the East Asian population
• FIN Frequency: Allele Frequency in the European (Finnish) population
• MID Frequency: Allele Frequency in the Middle Eastern population
• NFE Frequency: Allele Frequency in the European (Non-Finnish) population
• Remaining Frequency: Allele Frequency in the remaining populations
• SAS Frequency: Allele Frequency in the South Asian population

Conserved Regions - Phast:

• Region Start: Genomic coordinate of the start of the conserved region
• Region End: Genomic coordinate of the end of the conserved region
• Phast name: Name of aligned element
• Score: Estimated probability score for conservation as determined from PHAST package (nominal range: 0-1000)

Conserved Regions - GERP++:

• Region Start: Genomic coordinate of the start of the conserved region
• Region End: Genomic coordinate of the end of the conserved region
• Element RS Score: Rejected Substitutions score for the conserved element as determined from GERP++ package
• Base RS Score: Rejected Substitutions score calculated per base as determined from GERP++ package

Biological Context - Reactome Pathways:

• Pathway: Link to Reactome Pathway
• Description: Pathway description
• Parents: Main parent(s) of the Pathway
• p-Value: Statistical significance of the Pathway calculated using the Fisher's Exact Test for all the genes involved in the original queryset
• Genes involved: Genes from the original queryset involved in the Pathway

Biological Context - KEGG Pathways:

• Term Id: Link to KEGG Pathway
• KEGG Term: Pathway description
• Overlap: Number of genes in the original query overlapping genes involved in pathway
• p-Value: Probability that the observed overlap occurred by random change. Calculated using GSEApy library.
• Adjusted p-Value: p-Value corrected for multiple testing
• Odds ratio: Quantifies the strength of the association between the overlapping genes and the pathway
• Combined score: Combination of the p-value and odds value
• Genes involved: Genes from the original queryset involved in the Pathway

Biological Context - Genotype/Tissue Expression GTEx:

• GTEx ID: Link to the variant in the GTEx Portal
• Gene: Ensembl gene
• Tissue: Tissue associated with gene
• p-Value: Probability that the observed association between the variant and gene expression occurred by chance
• Beta: Regression coefficient for the linear model
• Normalised Effect Size: Metric to compare effect sizes across different genes and tissues
• Slope Standard Error: Uncertainty in the slope estimate

ClinVar:

• Phenotypes: List of phenotypes associated with the variant
• Significance: Whether identified as Pathogenic, Benign or Uncertain
• Review Status: Review status recorded in ClinVar
• ClinVar ID: ID of the Variant in ClinVar

Cosmic:

• Gene: Gene affected by the variant
• AA Mutation: HGVS mutation on the protein
• Cosmic Mutation: Cosmic ID for the mutation
• PubMed ID: PubMed ID for the publication of the study
• Somatic Status: Status reported of the mutation
• Tumour Source: Source of tumour tissue sample e.g. primary, metastasis.
• Site: Primary site and site subtypes
• Histology: Primary histology and histology subtypes

GWAS Catalog:

• Genes: List of genes affected by the variant
• Disease: Disease or trait examined in the study
• p-Value: Reported p-Value for strongest SNP risk allele
• PubMed ID: PubMed ID for the publication of the study
• Sample: Sample size and ancestry description for stage 1 of GWAS